Sermorelinalso known as GHRH is a bio-identical hormone that has recently been genetically engineered to stimulate the secretion of Growth Hormone Releasing Hormone (GHRH) from the hypothalamus, a gland adjacent to the pituitary gland. GHRH is a peptide that contains the first 29 amino acids of our own GH. These 29 amino acids are the active amino acids of GHRH. It is GHRH that stimulates the pituitary glands to release GH. As we get older, the hormones produced by the anterior pituitary are depleted. It has now been shown that GHRH can restore the GH-RNA to a youthful level causing elevation of levels of IGF-1.
GHRP2 and GHRP6
GHRPs are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH) through the activation of a specific, G protein-coupled receptor.
Growth Hormone Releasing Peptides substantially stimulates the pituitary glands increased natural production of the bodys own endogenous human growth hormone (HGH).
Growth-Hormone-Releasing-Peptide-Two (GHRP-2) is a synthetic ghrelin analogue. It causes the release of endogenous (internal) Growth Hormone (GH) from somatotropes in the anterior pituitary gland. It works synergistically with GHRHs and lacks the lipogenic properties (fat creation/storage) of ghrelin. GHRP-2 excites the hypothalamus and causes a high release of GH which tapers back to baseline by the third hour post admin. This pulse closely represents that of the natural pulse of the human body giving it an advantage over synthetic GH use.
Benefits and Potential of GHRP-2
GHRP-2 has great benefit and potential in athletes and wellness. GHRP-2 has been studied and shown to be effective in treating age-related GH decline when used in combination with a GHRH. GHRP-2 when use with an equal dose of a GHRH creates a 3-hour pulse of GH that is double the amplitude of 8IU of synthetic GH. This makes it a more effective, healthier substitute to synthetic Growth Hormone with the added safety and lower cost benefits.
Growth-Hormone-Releasing-Peptide-6 (GHRP-6) is a Growth Hormone (GH) secretagogue and ghrelin mimetic.The peptide GHRP-6 works similarly to GHRP-2 however it induces hunger consistently in mammals. It also does have some lipogenic properties that are dependent on the status on insulin and glucose.
Benefits and Potential of GHRP-6
Again, similar to GHRP-2 and, GHRP-6 has many benefits and uses. Due to the increased GH release, the following benefits may be observed:
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