Exploring the connection between obesity & severe COVID-19 infections – Cardiovascular Business


Posted: July 7, 2020 at 5:57 pm

Obesity is associated with a greater risk of a severe COVID-19 infection, according to a new analysis published in Circulation. It may not necessarily be an independent risk factor, the authors noted, but it appears to be a consistent indicator that serious complications may arise.

We suggest obesity or excess ectopic fat deposition may be a unifying risk factor for severe COVID-19 infection, reducing protective cardiorespiratory reserve as well as potentiating the immune dysregulation that appears, at least in part, to mediate the progression to critical illness and organ failure in a proportion of patients with COVID-19, wrote lead author Naveed Sattar, MD, University of Glasgow, and colleagues.

Sattar et al. highlighted data from multiple studies, noting that individuals with a BMI higher than 35 appeared to be at an especially high risk. Obesity is causally related to numerous conditions, they wrote, and those associations all seem relevant as healthcare providers consider how patients could be affectedby this ongoing pandemic.

There are multiple pathways by which obesity (or excess ectopic fat) may increase the effect of COVID-19 infection, the authors added. These include underlying impairments in cardiovascular, respiratory, metabolic, and thrombotic pathways in relation to obesity, all of which reduce reserve and ability to cope with COVID-19 infection and the secondary immune reaction to it.

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Exploring the connection between obesity & severe COVID-19 infections - Cardiovascular Business

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