In 1997 three collegiate wrestlers made national headlines by dying. The story was considered newsworthy not only because the three young men had no history of illness but also because of accusations that their use of creatine supplements had led to their untimely deaths. Subsequent investigation revealed that creatine had nothing to do with it. There was no evidence that theyd taken supplements in the days before they died. What really killed them was dehydration, leading to kidney shutdown in two of the wrestlers.
Making weight is common in many sports, and bodybuilders often try to reduce bodyfat before a competition in order to highlight muscularity. The sensible method of losing weight is a longer, slower process. Most professional bodybuilders begin their contest preparations anywhere from three to six months out from a contest; losing weight slowly preserves muscle and strength. Still, its not uncommon for athletes to resort to sudden-death techniques of dropping weight that, sadly, can result in just that. Few athletes pay the ultimate price for injudicious dieting and training, but they do pay in more subtle ways.
The cost of dropping weight too rapidly was highlighted in a recent study of 18 elite wrestlers who competed nationally and internationally.1 Rapid-weight-loss programs are common in wrestling. Scientists monitored changes in the wrestlers body composition, body chemistry, minerals and hormones over the course of a two-to-three-week weight-reduction regimen.
The wrestlersaverage age 21 with an age range of 17 to 31were told to restrict their intake of carbohydrates and fat but keep their protein intake high, at two kilograms per pound of bodyweight, to prevent loss of lean mass. Their daily calorie intake was 800 to 2,000, and they stimulated dehydration during the last two days through heavy training and hot saunas, as well as restricting fluid intake and lowering their daily calories to a maximum of 1,000. The wrestlers also took various minerals:
500 milligrams of potassium five times daily
247.5 milligrams of magnesium five times daily
300 milligrams of calcium twice daily
Although the authors didnt discuss it, the wrestlers were taking low-quality minerals. They used potassium chloride, which can have caustic effects in the gastrointestinal tract; magnesium hydroxide, which rapidly brings on diarrhea; and calcium carbonate, which is chalk and harder to absorb than other forms of supplemental calcium. Even so, getting some minerals is better than getting none. Odds are that their restricted diet was low on those minerals and that side effects would have been much more in evidence without them. Remember, the wrestlers were actively seeking dehydration to foster weight loss, and dehydration causes mineral loss.
The weight-reduction program proved successful. The greatest overall weight loss was 11 percent, along with an average 6.9 percent drop in bodyfatnot bad for only two weeks. The wrestler also lost 2.9 percent lean mass, which could be a combination of water and muscle.
Most alarming was the programs effect on testosterone. The average drop was 33 percent, along with a 47 percent drop in luteinizing hormone, or LH, a pituitary hormone that controls testosterone synthesis. Even worse, the wrestlers sex hormone-binding globulin went up by 21 percent. SHBG binds active testosterone in the blood, and the more SHBG your body has, the less testosterone you have in your blood.
The fact that LH dropped by 47 percent reflects insufficient food intake, coupled with high stress conditions. Note that the wrestlers didnt do any aerobics during their weight-loss program, only anaerobic exercise, such as weight training and wrestling practice. Increased aerobic exercise, especially when accompanied by an ultralow-calorie diet, is associated with low testosterone and higher cortisol counts. The wrestlers reported increased fatigue, tension and anger and reduced vigor. They also had trouble sleeping, and stress from that further depleted their testosterone.
Insulinlike growth-factor 1 did not take a hit. IGF-1 is vital for muscle repair. The authors think that the tapering exercise program the wrestlers used may have maintained their IGF-1, or perhaps the program didnt last long enough to reflect any changes in that hormone. I would suggest two other possible mechanisms. IGF-1 is related to both calorie and protein intake. The wrestlers higher protein intake may have preserved their IGF-1, along with their continued training. In addition, the carbohydrate and fat may have spurred an increased release of growth hormone, which would be reflected by a higher amount of IGF-1.
The information in this study applies to bodybuilders who dont use anabolic drugs. Natural bodybuilders who drop weight too fast by extreme dieting and training will likely experience rapid drops in testosterone and growth hormone, as well as a rise in cortisol. Result: significant muscle loss, along with a slowdown in bodyfat loss due to lack of anabolic hormone support and a drop in active thyroid hormone. So if you avoid pharmaceutical hormones, you should also avoid crash dieting, unless you also want to crash your muscle gains.
A World Without Estrogen
Bodybuilders hear a lot of bad things about estrogen these days. Its evil reputation is almost on par with cortisol, although the two hormones have little in common other than both being steroids. Steroids, in case youre confused, refers to the molecular structure of the hormones and the fact that theyre produced from cholesterol. Estrogen, testosterone, cortisol, aldosterone and activated vitamin D are all steroids.
Judging by the number of supplements that claim to lower estrogen, it appears to be a definite liability for bodybuilders. In males having an abundance of estrogen is linked to water retentioncaused by increased aldosterone and the resulting sodium retentionsubcutaneous bodyfat and gynecomastia. The higher-than-usual estrogen seen in some bodybuilders is caused when aromatase, a ubiquitous enzyme found throughout the body but particularly concentrated in fat tissue, converts anabolic steroids to estrogen.
Bodybuilders who use large doses of anabolic steroids may have more estrogen than young women do. Normally, men have about 10 times as much testosterone as women, only 0.8 percent of which is converted into estrogen. That scenario changes in the presence of huge doses of anabolic steroids, which is why bodybuilders who juice also take drugs that either block estrogen cell receptors (Nolvadex), or inhibit the aromatase enzyme directly (Arimidex).
Whats frequently overlooked is that estrogen may have benefits. It appears to interact with androgen cell receptors, amplifying the impact of anabolic steroids. Estrogen also maintains IGF-1, which has anabolic functions in muscle besides helping muscle repair after exercise. Some emerging evidence shows that estrogen may play a role in preventing excessive muscle damage during exercise.
From a cardiovascular protection viewpoint, estrogen is a paradox. In women it appears to protect against cardiovascular disease by fostering higher levels of high-density lipoprotein, the good kind of cholesterol, and maintaining the elasticity of arteries. Having supple arteries helps protect against atherosclerosis and high blood pressure.
Purveyors of anti-estrogen supplements frequently advise getting off them because estrogen offers cardiovascular protection in men, but that idea doesnt jibe with the latest research. In a recent study that involved 933 young men, average age 19, researchers looked at the connection between the sex hormones estradiol, estrone, testosterone and androstenedione and such major cardiovascular-disease risk factors as high blood cholesterol, high blood pressure and excess weight.2 Positive links emerged between higher estradiol and total cholesterol, along with lower HDL. Having more estrone, a weaker estrogen, was linked with increased total cholesterol and heightened LDL, which is also linked to cardiovascular disease. Testosterone, which is often accused of promoting cardiovascular disease in men, had no effect on any risk factors.
When estrogens are given to older men in hopes of preventing cardiovascular disease, they usually increase they incidence of it. Clearly, estrogens are of no benefit whatsoever to men of any age. Why they appear to protect women from cardiovascular disease is still a biological mystery.
Some scientists suggest that increased estrogen, coupled with lower testosterone, is responsible for many of the ills linked to the aging process in men. Older men tend to have more bodyfat, and more bodyfat means more aromatase activity and more estrogen. While there is only one known androgen cell receptor, estrogen has two: estrogen receptor alpha (ERA) and estrogen receptor beta (ERB). Androgens reduce the production of ERB, which in turn blunts the activity of GLUT4, a vital glucose transporter protein, in muscle. A loss of GLUT4 activity can increase insulin resistance and obesity, and when testosterone recedes, ERB activity increases. In addition, having lower testosterone leads to having more visceral, or deep-lying, abdominal fat, which is most unhealthful. Unlike subcutaneous fat, which remains in one place, visceral fat is constantly released into the blood, where its transported to the liver. There it makes mischief as a prime cause of the metabolic syndrome, cardiovascular disease, high blood pressure and diabetes. Visceral fat is also rich in aromatase.
Some researchers suggest that because of the metabolic problem discussed above, routine use of aromatase-inhibiting drugs should be considered a sensible treatment for men who have higher estrogen and lower testosterone. Other researchers, however, point to the effects of a total lack of aromatase in animals bred to lack genes that produce it or humans born without the same genes. Aromatase-knockout mice, as theyre called, have twice as much bodyfat as their normal littermates. They also accumulate excess fat in their livers, a condition that is corrected if they receive estrogen. They have resting insulin three times greater than other mice. Human beings who lack aromatase have similar conditions, including higher glucose, insulin and total and low-density lipoprotein, which places them at risk for cardiovascular disease. The abnormalities are all reversed in men who are given estrogen.
How that relates to those who use drugs that interfere with estrogen activity becomes clear when you consider that labels on over-the-counter versions of aromatase inhibitors always warn users not to take them all the time. Thats good advice. None of the supplements completely knock out estrogen. A study3 of young men given one milligram daily of Arimidex, which is far more potent than any over-the-counter estrogen blocker, for 10 weeks found a 50 percent reduction in estradiol, the most active form of estrogen. When you block estrogen in men, you get a reciprocal increase in testosterone. Taking Arimidex caused a slight rise in testosterone in the young men, but in older men who were low in testosterone, taking the same drug in the same dose normalized testosterone. So the effect on testosterone depends on how much your body is making in the first place. As weve seen, because estrogen also increases SHBG and ties up testosterone in the blood, lowering estrogen boosts free, or active, testosterone by blunting SHBG production in the liver.
A higher count of free testosterone, however, comes with a price. Estrogen-blocking supplements dont affect another enzyme, 5-alpha reductase, which converts free testosterone into dihydrotestosterone, the hormone linked to male-pattern baldness, acne and prostate disease. So in effect, you are trading one set of problems (high estrogen) for another (high DHT). The effect isnt significant enough to cause problems with short-term use, but not getting off such supplements periodically could present some real problems.
1 Karila, T.A.M., et al. (2008). Rapid weight loss decreases serum testosterone. Int J Sports Med. 29(11):872-7.
2 Tomaszewski, M., et al. (2008). Association between lipid profile and circulating concentrations of estrogens in young men. Atheroscl. In press.
3 Mauras, N., et al. (2000). Estrogen suppression in males: metabolic effects. J Clin Endocrin Metabol. 85:2370-2377. IM
- The Untold Testosterone Story for Women | Dr. Tami - May 31st, 2018
- Pregnenolone Weight Loss Regimen: The Master Hormone for ... - February 21st, 2018
- Fitness for Weight Loss Blog - February 8th, 2018
- Dr. Marlowe's Weight Loss Institute. 400 Clarice Ave ... - February 8th, 2018
- Testosterone and Weight Loss -How do they affect each other? - January 31st, 2018
- Synergenx Health, Testosterone & Weight Loss - Yelp - December 25th, 2017
- Testosterone - Medical Center Weight Loss Clinic - San ... - October 6th, 2017
- Testosterone and Weight Loss - October 1st, 2017
- Weight and cancer risk - MyDaytonDailyNews - September 6th, 2017
- How to ensure your body gets the right balance of hormones - Economic Times - September 6th, 2017
- Day or night ... why anytime is the right time for getting a good workout - Belfast Telegraph - September 6th, 2017
- Chemotherapy drugs for colon cancer - Clenbuterol cycle for female weight loss - Magnetic Media (press release) - September 3rd, 2017
- Five ways to overcome testosterone decline - The Sport Review - September 3rd, 2017
- polycystic ovarian syndrome: A common cause of female infertility - NIGERIAN TRIBUNE (press release) (blog) - September 2nd, 2017
- How obesity can lead to erectile dysfunction - TheHealthSite - September 2nd, 2017
- A story of 'enduranz' - Business Mirror - August 31st, 2017
- Why you need to go off keto - Mumbai Mirror - August 28th, 2017
- Here Are The Answers To The Most Asked Question About Bodybuilding Steroids - MensXP.com - August 25th, 2017
- Obesity and its implications on sexual heath - The Navhind Times - August 25th, 2017
- How food can help, harm fertility - Fort Wayne Journal Gazette - August 25th, 2017
- Male hair loss: Three ways to reduce YOUR risk of going bald - Express.co.uk - August 25th, 2017
- Bigelow Center presents free talk by Dr. Woznitzer - Fairfield Sun - August 24th, 2017
- Real Men Wear Gowns: Why men aren't taking their health seriously - KARE - August 18th, 2017
- SEXUAL HEALTH: It's no laughing matter - Daily Nation - August 18th, 2017
- Researchers Track an Unlikely Culprit in Weight Gain - New York Times - August 11th, 2017
- Top health benefits of green chillies - The Statesman - August 11th, 2017
- The Strength Of Strength Training - Outlook India - August 11th, 2017
- The best time of the day for your team to be productive - Human Resources Online - August 11th, 2017
- Man flu is real, but women get more autoimmune diseases and allergies - Medical Xpress - August 7th, 2017
- Albuterol sulfate overdose treatment - How fast does albuterol work for weight loss - Hayati Magazine (blog) - August 2nd, 2017
- Myth 1: Weightlifting Makes You Bulk Up - POPSUGAR Australia - August 2nd, 2017
- Fitness trends - Daily News & Analysis - August 2nd, 2017
- Trying to conceive? Think about your diet - Independent Online - August 2nd, 2017
- FINA Announces Three Doping Suspensions - SwimSwam - July 31st, 2017
- Can Testosterone Help You Lose Weight? | Men's Fitness - July 31st, 2017
- Trying to conceive? Think about what you're eating - Stuff.co.nz - July 31st, 2017
- AbbVie Ordered to Pay $150 Million Damages in 'Low-T' Trial - Bloomberg - July 31st, 2017
- What military recruiters aren't telling women: You'll face disproportionate health risks - Los Angeles Times - July 31st, 2017
- The Top 5 Myths About Weightlifting That Need to Be Busted - POPSUGAR - July 31st, 2017
- 7 Beets Benefits For Your Health, From Losing Weight To Better Sex - Medical Daily - July 31st, 2017
- What Men should Know About Testosterone and Weight Loss - July 10th, 2017
- 5 'No Brainer' Rules Of Starting A Weight Loss Journey For Beginners - MensXP.com - July 10th, 2017
- Why Can't I Get Rid Of My Belly Fat? Here Are 7 Reasons - Huffington Post Australia - July 10th, 2017
- Vitamin D Deficiency in Men - Reports Healthcare - July 8th, 2017
- Amazing Weight Loss & Wellness - Flower Mound, TX | (972 ... - July 8th, 2017
- Does when we eat matter - Independent.ie - July 8th, 2017